As the hero player, you probably don't need to be told how big it is to put the right glyphs on the right team characters. It's equally important as the villain player to try to keep those "right glyphs" away from your opponent's best characters. Information Leak (and its Science/Combat counterpart, Mind Probe) is a great tool for the job.

And while it's worth a slot in many different kinds of decks, it especially shines when Robert Kinsey or Frank Simmons are around to take advantage of its Political trait.

Obviously, when this obstacle works, you'll be looking for characters who need specific glyphs to "switch on" their text, to then move those glyphs away. But another subtle (yet just as important) strategy is to move glyphs to characters who have text that triggers "each time he earns a different glyph." When you move a glyph onto a character like Ishta, Thor, Asgard Ally, or Jack O'Neill, Witty Explorer, you potentially take away a chance for your opponent to actually earn that glyph later in the game and use the character's text against you.